Faculty of Medicine: Research Data
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- Research DataPlasma lipidomic and metabolomic profiles in high grade glioma patients before and after 72h pre-surgery water-only fasting2024Diffuse gliomas are incurable brain cancers. Amongst these, glioblastoma (GB) is the most aggressive primary brain tumor and has a poor prognosis despite the use of multimodal therapy. Therefore, novel therapeutic approaches are urgently needed. Calorie-restricted diets have emerged as putative strategy to augment anti-cancer therapies. We employed UHPLC-high resolution mass spectrometry analyses of plasma lipids and polar metabolites to assess systemic metabolic effects of a 72 h pre-surgery fasting course in IDH-wildtype glioma patients (n = 9 GB and n = 1 diffuse pediatric type high-grade H3/IDH wildtype) who participated in the prospective ERGO3 trial (NCT04461938). Fasting reduced lysophosphatidylcholines (LPC) and lysophosphatidylethanolamines (LPE) and their ether-bound derivatives (LPC-O, LPE-O), and increased free fatty acids and carnitines. Triglyceride (TG) profiles shifted from short-chain TGs (42-48 C-atoms, reduced) to very long chain TGs (58-60 C-atoms, increased) indicating an exploitation of neutral lipid stores. Branched chain amino acids, aminobutyric acid and uric acids were increased, and glucose reduced as expected after fasting. Analyses of individual lipid/metabolite profiles in comparison with the average profile revealed that all subjects adhered to the fasting scheme with interindividual substantial differences in fasting efficacy, apparently independent from BMI, MGMT promoter methylation status or low-dose dexamethasone treatment. LPCs were reduced in all fasted patients. This is to our knowledge the first study that evaluated effects of fasting on systemic lipid/metabolite levels in GB patients. Our results are a prerequisite for advancing fasting interventions as a component of a potential metabolic tumor therapy. A fasting-induced systemic reduction of LPCs may reduce LPC-dependent omega-3 lipid import into the brain and, hence, lipid supply necessary for glioma growth.
39 - Research DataEffect of stem design and positioning on the leg axis after total hip arthroplasty: a secondary analysis2024Abstract: Background/Objectives: Various parameters, like femoral offset and leg length, are associated with good patient outcomes after total hip arthroplasty. In this prospective study, the effects of stem design, its placement in the proximal femur and the resulting femoral offset on the total leg axis were investigated. Methods: The 27 patients included in this study received biplanar radiography (EOS® Imaging) with 3D reconstruction using sterEOS software both preoperatively and postoperatively. For all leg alignment parameters obtained from the 3D reconstruction and from measurements using mediCAD, the deltas between the postoperative and preoperative values were determined. Patients were divided into those who received a short-stem prosthesis and those who received a straight-stem prosthesis. Results: The change in femoral offset with the implantation of a short-stem prosthesis was significantly greater than that with the implantation of a straight-stem prosthesis (11.4 ± 5.9 vs. 4.6 ± 7.4 mm, p = 0.014). Compared with the straight-stem implantation, short-stem implantation caused a significantly greater increase in the varus orientation of the leg (-1.4 ± 0.9 vs. -0.4 ± 1.4 °, p = 0.048). There was no significant difference in the positioning of the short-stem prosthesis compared to the straight-stem prosthesis in the proximal femur (3.6 ± 3.1 vs. 2.6 ± 1.9 °, p = 0.317). Conclusions: These findings substantiate the impact of prosthesis design on offset and leg alignment. The implantation of short-stems is more variable and requires precise planning. Intraoperative non-physiological offset changes and varus deviation of the leg axis should be avoided. Trial registration: The study was retrospectively registered with the German Clinical Trials Register (DRKS) under the number DRKS00015053 on the 1st of August 2018.
32 3 - Research DataData for Inflammatory biotype of ADHD is linked to chronic stress: a data-driven analysis of the inflammatory pro-teome2023Protein Data and Grouping variable for the Article "Inflammatory biotype of ADHD is linked to chronic stress: a data-driven analysis of the inflammatory proteome" published in Translational Psychiatry
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