Goethe University Data Repository (GUDe)
The archiving and publication platform for scientific research data at Goethe University Frankfurt.
The Goethe University Data Repository (GUDe) provides a platform for its members to electronically archive, share, and publish their research data. GUDe is jointly operated by the University Library and the University Data Center of the Goethe University. The metadata of all public content is freely available and indexed by search engines as well as scientific web services. GUDe follows the FAIR principles for long-term accessibility (minimum 10 years), allows for reliable citation via DOIs as well as cooperative access to non-public data and operates on DSpace-CRIS v7.
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Research Data
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Recent Additions
- Research DataRNA•DNA:DNA Triplex Formation Modulates Individual Base Pair Stabilities in the DNA Target Duplex Revealed by NMR Observed Solvent Exchange2025-09-30Long non-coding RNAs (lncRNAs) play a key role in numerous biological processes, including gene regulation. One potential mechanism involves the formation of RNA•DNA:DNA triplex structures, where the lncRNA binds in the major groove of a target DNA via Hoogsteen base pairs. Here, we investigated the impact of the lncRNA binding on the stability of the DNA duplex target to gain more insights into the triplex formation process. Quantification of the temperature-dependent imino proton solvent exchange allows the determination of the changes of individual DNA duplex base pairs upon triplex formation. The data shown here demonstrate that triplex formation alters DNA structure and stability by affecting both hydrogen bonding and base-stacking interactions. These thermodynamic insights support the prediction of triplex stability and enhance the understanding of RNA•DNA:DNA triplex formation.
8 2 - Research DataDas Ringen um Souveränität an der polnisch-belarussischen Grenze. Diskursive Strategien der polnischen Regierung und polnischen Graswurzelbewegung – Eine ethnomethodologische Konversationsanalyse2025-09-19Die Arbeit untersucht das polnisch-belarussische Grenzregime im Kontext der Migrationsbewegungen ab Juni 2021. Während der polnische Staat die Ereignisse als geopolitische Sicherheitskrise rahmt und mit massiven Grenzsicherungsmaßnahmen reagiert, begreifen zivilgesellschaftliche Graswurzelbewegungen – insbesondere die Grupa Granica – die Situation als humanitäre Krise. Mittels der ethnomethodologischen Konversationsanalyse werden zentrale Dokumente beider Seiten hinsichtlich der in ihnen verwendeten diskursiven Strategien analysiert. Im Zentrum steht die Frage, wie die beteiligten Akteur*innen die Ereignisse an der Grenze bearbeiten und welche impliziten Wissensordnungen dabei aktiviert werden. Die Analyse zeigt, dass staatliche und zivilgesellschaftliche Akteur*innen in ihrer jeweiligen Bearbeitung der Krise auf teilweise gemeinsame Wissensbestände zurückgreifen. Damit wird das Grenzregime als komplexes Zusammenspiel unterschiedlicher Akteur*innen sichtbar, das sich nicht entlang einfacherer Oppositionslinien beschreiben lässt. Die Arbeit leistet so einen Beitrag zur empirischen fundierten Ausdifferenzierung des polnisch-belarussischen Grenzregimes und zeigt, wie staatliche und nicht-staatliche Akteur*innen dieses in anhaltenden Aushandlungsprozessen wechselseitig konstituieren. unter: https://www.fb03.uni-frankfurt.de/116042947/DiPL_Schriftenreihe DOI: 10.21248/gups.fpfd.008
13 6 - Research DataDissecting the stabilities of tetrads in G-quadruplexes by hydrogen exchange to derive a structure-activity relation for a thrombin-binding DNA G-quadruplex aptamer2025-09-18Guanosine- and deoxyguanosine-rich nucleic acids can form G-quadruplex structures (G4) that are stabilized by guanine tetrads (G4 tetrads). G4s find numerous application in biotechnology and we study here the so called TBA aptamer, developed by SELEX procedures, that adopts a G4 conformation and inhibits clotting of thrombin. We investigate the TBA G4 and its variants with either four adenosine desoxynucleotides or four abasic sites attached either to the 5’-terminus (A4-TBA and ab4-TBA) or the 3’-terminus (TBA-ab4 and TBA-A4). Biophysical characterization of the variants reveals that the structure of the aptamer remains unchanged but that their different thermal stabilities correlate with the anti-clotting activity of TBA. Hydrogen exchange quantified by nuclear magnetic resonance spectroscopy (NMR) reveals individual G4 tetrad thermodynamics. Our data indicate that while enthalpy, entropy and free energy of base pair opening shows surprisingly low variation, a hotspot for stabilization of the G4 is present at the 3’-terminal tetrad of TBA.
9 3 - Research DataIn situ GJ complex in C. elegans2025-09-12Tilt series, alignment and mdoc files as well as reconstructed volumes obtained from cryo electron tomography of C. elegans primary cell culture.
27 2 - Research DataDritte universitätsweite Studierendenbefragung 2022/23 der Goethe Universität Gesamtbericht2024-03-08Die dritte universitätsweite Studierendenbefragung der Goethe-Universität Frankfurt fand von Ende November 2022 bis Ende Januar 2023 statt und setzte den fünfjährigen Turnus nach 2012/13 und 2017/18 fort. Ziel der Befragung ist die datenbasierte Identifikation von Optimierungspotenzialen sowie zentralen Themen für die Weiterentwicklung von Studium und Lehre. Die Befragung stellt damit ein zentrales Instrument des Qualitätsmanagementsystems der Universität dar. Im vorliegenden Bericht werden die Ergebnisse des Basisbogens der Befragung 2023 dargestellt. Analysiert werden vornehmlich einzelne Fragestellungen deskriptiv; die Ergebnisse werden in Form von Tabellen und Grafiken aufbereitet. Erfasst wurden unter anderem die persönliche Lebenssituation, Bildungsverläufe, Einstellungen und Motivation, Studien- und Prüfungsbedingungen, Erfahrungen mit Diskriminierung und Barrierefreiheit, Unterstützungsangebote, Lehrverhalten sowie Lernverhalten und Lernergebnisse. Damit wird ein umfassender Einblick in die Situation und Perspektive der Studierenden ermöglicht. Die Ergebnisse können auf gesamtuniversitärer Ebene in hochschulstrategische Entscheidungen einfließen sowie auf Fachbereichs- und Studiengangebene die Weiterentwicklung und Reakkreditierung unterstützen. Der Bericht richtet sich an Entscheidungsträger*innen, zentrale Einrichtungen und die Hochschulöffentlichkeit und soll eine kompakte, datenbasierte Grundlage für Diskussionen und Entwicklungen im Bereich Studium und Lehre bieten.
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- Research DataThe global water resources and use model WaterGAP v2.2e - model output driven by gswp3-w5e5 and historical setup of direct human impacts2023-10-20Trautmann, TimAckermann, SebastianCáceres, DeniseFlörke, MartinaGerdener, HelenaKynast, EllenPeiris, Thedini AsaliSchiebener, LeonieSchumacher, MaikeAssessing global freshwater resources and human water use is of value for a number of needs but challenging. The global water use and water availability model WaterGAP has been in development since 1996 and has served a range of applications such as assessments of global water resources and water stress, also under the impact of climate change, drought hazard quantification, Life Cycle Assessments, water (over)use and consequently depletion of water resources and a better understanding of terrestrial water storage variations (jointly with satellite observations). Here, the reader can download model output for the time period 1901-2019 that was computed by driving WaterGAP v2.2e by four alternative climate datasets (climate forcings) that were generated in the ISIMIP context (https://www.isimip.org) and are described in https://data.isimip.org/10.48364/ISIMIP.982724. For two climate datasets, model runs up to 2021 or 2022 are available. For comparison, output of a version of WaterGAP v2.2d that is calibrated to the same dataset of observed streamflow as WaterGAP v2.2e is provided. Each of the climate forcing-model version combinations is run in two socio-economic settings, histsoc and nosoc. In nosoc, human water use is set to zero and man-made reservoirs are assumed to be non-existant. In the paper connected to this dataset (to be submitted to Geoscientific Model Development), the newest model version, WaterGAP v2.2e is described by providing the modifications to the previous version v2.2d (Müller Schmied et al. 2021) and the corresponding changes in model output. The most important and requested model outputs (total water storage variations, streamflow and water use) are evaluated against observation data. Standard model output is described as well as the specifics of the WaterGAP contribution within the ISIMIP framework. Müller Schmied, H., Cáceres, D., Eisner, S., Flörke, M., Herbert, C., Niemann, C., Peiris, T. A., Popat, E., Portmann, F. T., Reinecke, R., Schumacher, M., Shadkam, S., Telteu, C.-E., Trautmann, T., Döll, P. (2021): The global water resources and use model WaterGAP v2.2d: Model description and evaluation. Geosci. Model Dev., 14, 1037–1079. https://doi.org/10.5194/gmd-14-1037-2021
1012 585 - Research DataThe global water resources and use model WaterGAP v2.2e - model output driven by gswp3-era5 and historical setup of direct human impacts2023-10-20Trautmann, TimAckermann, SebastianCáceres, DeniseFlörke, MartinaGerdener, HelenaKynast, EllenPeiris, Thedini AsaliSchiebener, LeonieSchumacher, MaikeAssessing global freshwater resources and human water use is of value for a number of needs but challenging. The global water use and water availability model WaterGAP has been in development since 1996 and has served a range of applications such as assessments of global water resources and water stress, also under the impact of climate change, drought hazard quantification, Life Cycle Assessments, water (over)use and consequently depletion of water resources and a better understanding of terrestrial water storage variations (jointly with satellite observations). Here, the reader can download model output for the time period 1901-2019 that was computed by driving WaterGAP v2.2e by four alternative climate datasets (climate forcings) that were generated in the ISIMIP context (https://www.isimip.org) and are described in https://data.isimip.org/10.48364/ISIMIP.982724. For two climate datasets, model runs up to 2021 or 2023 are available. For comparison, output of a version of WaterGAP v2.2d that is calibrated to the same dataset of observed streamflow as WaterGAP v2.2e is provided. Each of the climate forcing-model version combinations is run in two socio-economic settings, histsoc and nosoc. In nosoc, human water use is set to zero and man-made reservoirs are assumed to be non-existant. In the paper connected to this dataset (in review with Geoscientific Model Development), the newest model version, WaterGAP v2.2e is described by providing the modifications to the previous version v2.2d (Müller Schmied et al. 2021) and the corresponding changes in model output. The most important and requested model outputs (total water storage variations, streamflow and water use) are evaluated against observation data. Standard model output is described as well as the specifics of the WaterGAP contribution within the ISIMIP framework. Müller Schmied, H., Cáceres, D., Eisner, S., Flörke, M., Herbert, C., Niemann, C., Peiris, T. A., Popat, E., Portmann, F. T., Reinecke, R., Schumacher, M., Shadkam, S., Telteu, C.-E., Trautmann, T., Döll, P. (2021): The global water resources and use model WaterGAP v2.2d: Model description and evaluation. Geosci. Model Dev., 14, 1037–1079. https://doi.org/10.5194/gmd-14-1037-2021
572 574 - Research DataA j_eff 12 Kitaev material on the triangular lattice: The case of NaRuO22023-06-07Motivated by recent reports of a quantum disordered ground state in the triangular lattice compound NaRuO$_2$, we derive a $j_{\rm eff}=1/2$ magnetic model for this system by means of first-principles calculations. The pseudospin Hamiltonian is dominated by bond-dependent off-diagonal $\Gamma$ interactions, complemented by a ferromagnetic Heisenberg exchange and a notably \emph{antiferromagnetic} Kitaev term. In addition to bilinear interactions, we find a sizable four-spin ring exchange contribution with a \emph{strongly anisotropic} character, which has been so far overlooked when modeling Kitaev materials. The analysis of the magnetic model, based on the minimization of the classical energy and exact diagonalization of the quantum Hamiltonian, points toward the existence of a rather robust easy-plane ferromagnetic order, which cannot be easily destabilized by physically relevant perturbations.
351 39 - Research DataSection-Type Constraints on the Choice of Linguistic Mechanisms in Research Articles: A Corpus-Based Approach2023This thesis investigates the structure of research articles in the field of Computational Linguistics with the goal of establishing that a set of distinctive linguistic features is associated with each section type. The empirical results of the study are derived from the quantitative and qualitative evaluation of research articles from the ACL Anthology Corpus. More than 20,000 articles were analyzed for the purpose of retrieving the target section types and extracting the predefined set of linguistic features from them. Approximately 1,100 articles were found to contain all of the following five section types: abstract, introduction, related work, discussion, and conclusion. These were chosen for the purpose of comparing the frequency of occurrence of the linguistic features across the section types. Making use of frameworks for Natural Language Processing, the Stanford CoreNLP Module, and the Python library SpaCy, as well as scripts created by the author, the frequency scores of the features were retrieved and analyzed with state-of-the-art statistical techniques. The results show that each section type possesses an individual profile of linguistic features which are associated with it more or less strongly. These section-feature associations are shown to be derivable from the hypothesized purpose of each section type. Overall, the findings reported in this thesis provide insights into the writing strategies that authors employ so that the overall goal of the research paper is achieved. The results of the thesis can find implementation in new state-of-the-art applications that assist academic writing and its evaluation in a way that provides the user with a more sophisticated, empirically based feedback on the relationship between linguistic mechanisms and text type. In addition, the potential of the identification of text-type specific linguistic characteristics (a text-feature mapping) can contribute to the development of more robust language-based models for disinformation detection.
256 10 - Research DataThe global water resources and use model WaterGAP v2.2e - daily water storage model output driven by gswp3-era5 and historical setup of direct human impacts2024-04-04Trautmann, TimAckermann, SebastianCáceres, DeniseFlörke, MartinaGerdener, HelenaKynast, EllenPeiris, Thedini AsaliSchiebener, LeonieSchumacher, MaikeAssessing global freshwater resources and human water use is of value for a number of needs but challenging. The global water use and water availability model WaterGAP has been in development since 1996 and has served a range of applications such as assessments of global water resources and water stress, also under the impact of climate change, drought hazard quantification, Life Cycle Assessments, water (over)use and consequently depletion of water resources and a better understanding of terrestrial water storage variations (jointly with satellite observations). Here, the reader can download daily model output for water storage variables for the time period 1901-2019 (2023) that was computed by driving WaterGAP v2.2e by two alternative climate datasets (climate forcings) that were generated in the ISIMIP context (https://www.isimip.org) and are described in https://data.isimip.org/10.48364/ISIMIP.982724. In the paper connected to this dataset (in review with Geoscientific Model Development), the newest model version, WaterGAP v2.2e is described by providing the modifications to the previous version v2.2d (Müller Schmied et al. 2021) and the corresponding changes in model output. Here, the single water storage compartments and terrestrial (total) water storage are provided.
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