Goethe University Data Repository (GUDe)
The archiving and publication platform for scientific research data at Goethe University Frankfurt.
The Goethe University Data Repository (GUDe) provides a platform for its members to electronically archive, share, and publish their research data. GUDe is jointly operated by the University Library and the University Data Center of the Goethe University. The metadata of all public content is freely available and indexed by search engines as well as scientific web services. GUDe follows the FAIR principles for long-term accessibility (minimum 10 years), allows for reliable citation via DOIs as well as cooperative access to non-public data and operates on DSpace-CRIS v7.
If you have any questions regarding the use of GUDe, please consult the user documentation.
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- Research DataThe Zuo1 C-terminal domain stabilizes the DNA guanosine quadruplex (G4) structures located on Chromosome IX in Saccharomyces cerevisiae2025-07-15Deoxyguanosine quadruplexes (G4s) are stable non-B-DNA structures that can affect transcription, replication, and genome stability. Depending on various factors including cation binding, G4s can fold into different topologies, which can be linked to distinct function. In cells, G4 folding, function, and unfolding is affected by proteins that specifically target G4s. Zuo1 is a G4-binding protein in yeast. To investigate Zuo1 binding and its consequences on G4 formation and topology, we characterized Zuo1’s interaction with G4s, both in vitro and in vivo. The main domain of Zuo1 interacting with the G4 structures is the C-terminus (Zuo1348-433). We characterized this interaction by combining NMR, smFRET, and in vivo experiments with a G4 located on yeast chromosome IX (G4IX). The Zuo1-G4IX interaction stabilizes this G4 structure and triggers conformational shifts depending on the cation environment. The data presented here demonstrates that Zuo1 is targeted to a specific conformational state of G4IX, where it modulates G4 topology and stabilizes the G4IX, ultimately contributing positively to genome stability.
1 4 - Research DataTargeting dynamics: A combined approach of in silico and in vitro screening of low molecular weight molecules binding to SARS-CoV-2 derived RNA elements2025-07-09We here present an approach combining virtual and nuclear magnetic resonance (NMR)-based screening to identify low molecular weight molecules (small molecules) targeting viral RNA elements from the SARS-CoV-2 genome. Our method uses high-resolution RNA structural ensembles of the conserved 5'-terminal stem-loop 1 (SL1) and the pseudoknot (PK) of the –1 programmed frameshift element as targets for binding of small molecules derived from a virtual library of compounds. The ensemble representation of the RNA structural dynamics was found to be crucial to faithfully identify RNA binders during virtual screening. Hits proposed by screening of the virtual library were probed for their binding to the two RNA elements by ligand- and target-based NMR experiments. This combined approach increases the specificity and efficiency of drug discovery by targeting specific of the multiple RNA conformations present within the RNA ensemble structure. Our results demonstrate that the integration of virtual and experimental NMR screening efficiently identifies RNA-binding small molecules as start molecular entities to advance RNA-targeted antiviral therapies. The strategy does not only apply to SARS-CoV-2, but also provides a rapid, highly specific route to discovering therapeutics for other RNA-based pathogens, highlighting the critical role of RNA structural data in enriching drug discovery efforts.
4 2 - Research DataSonderpädagogische Feststellungsgutachten und Beratungsgespräche zu: Diagnostische Praxis zur Feststellung sonderpädagogischen Förderbedarfs und Bundeslanddisparitäten im Kontext der UN-Behindertenrechtskonvention. Datenkollektion zum Förderschwerpunkt geistige Entwicklung2025-06-25Die Datenkollektion umfasst insgesamt 10 Fälle die jeweils aus einem sonderpädagogischen Festellungsgutachten und einem Transkript des Beratungsgesprächs bestehen. Darüber hinaus sind zu jedem Fall ein kurzes Abstract sowie eine Erhebungs- und Projektbeschreibung vorhanden. In den Feststellungsgutachten werden unterschiedliche Informationen eingeholt (z.B. medizinische Vorgeschichte, Kind-Umfeld-Analyse, Befunde aus Beobachtungen, Gesprächen und der Durchführung standardisierter Testverfahren), um einen sonderpädagogischen Förderbedarf zu begründen. Die Beratungsgespräche dienen dazu, die Sorgeberechtigten über die Befunde aus den sonderpädagogischen Feststellungsgutachten zu informieren und eine gemeinsame Entscheidung über die Feststellung des Förderbedarfs zu treffen.
86 - Research DataSonderpädagogische Feststellungsgutachten und Beratungsgespräche zu: Diagnostische Praxis zur Feststellung sonderpädagogischen Förderbedarfs und Bundeslanddisparitäten im Kontext der UN-Behindertenrechtskonvention. Datenkollektion zum Förderschwerpunkt Autismus2025-06-23Die Datenkollektion umfasst insgesamt 5 Fälle die jeweils aus einem sonderpädagogischen Festellungsgutachten und einem Transkript des Beratungsgesprächs bestehen. Darüber hinaus sind zu jedem Fall ein kurzes Abstract sowie eine Erhebungs- und Projektbeschreibung vorhanden. In den Feststellungsgutachten werden unterschiedliche Informationen eingeholt (z.B. medizinische Vorgeschichte, Kind-Umfeld-Analyse, Befunde aus Beobachtungen, Gesprächen und der Durchführung standardisierter Testverfahren), um einen sonderpädagogischen Förderbedarf zu begründen. Die Beratungsgespräche dienen dazu, die Sorgeberechtigten über die Befunde aus den sonderpädagogischen Feststellungsgutachten zu informieren und eine gemeinsame Entscheidung über die Feststellung des Förderbedarfs zu treffen.
91 7 - Research DataSonderpädagogische Feststellungsgutachten und Beratungsgespräche zu: Diagnostische Praxis zur Feststellung sonderpädagogischen Förderbedarfs und Bundeslanddisparitäten im Kontext der UN-Behindertenrechtskonvention. Datenkollektion zum Förderschwerpunkt Sprache2025-06-25Die Datenkollektion umfasst insgesamt 13 Fälle die jeweils aus einem sonderpädagogischen Festellungsgutachten und einem Transkript des Beratungsgesprächs bestehen. Darüber hinaus sind zu jedem Fall ein kurzes Abstract sowie eine Erhebungs- und Projektbeschreibung vorhanden. In den Feststellungsgutachten werden unterschiedliche Informationen eingeholt (z.B. medizinische Vorgeschichte, Kind-Umfeld-Analyse, Befunde aus Beobachtungen, Gesprächen und der Durchführung standardisierter Testverfahren), um einen sonderpädagogischen Förderbedarf zu begründen. Die Beratungsgespräche dienen dazu, die Sorgeberechtigten über die Befunde aus den sonderpädagogischen Feststellungsgutachten zu informieren und eine gemeinsame Entscheidung über die Feststellung des Förderbedarfs zu treffen.
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- Research DataThe global water resources and use model WaterGAP v2.2e - model output driven by gswp3-w5e5 and historical setup of direct human impacts2023-10-20Trautmann, TimAckermann, SebastianCáceres, DeniseFlörke, MartinaGerdener, HelenaKynast, EllenPeiris, Thedini AsaliSchiebener, LeonieSchumacher, MaikeAssessing global freshwater resources and human water use is of value for a number of needs but challenging. The global water use and water availability model WaterGAP has been in development since 1996 and has served a range of applications such as assessments of global water resources and water stress, also under the impact of climate change, drought hazard quantification, Life Cycle Assessments, water (over)use and consequently depletion of water resources and a better understanding of terrestrial water storage variations (jointly with satellite observations). Here, the reader can download model output for the time period 1901-2019 that was computed by driving WaterGAP v2.2e by four alternative climate datasets (climate forcings) that were generated in the ISIMIP context (https://www.isimip.org) and are described in https://data.isimip.org/10.48364/ISIMIP.982724. For two climate datasets, model runs up to 2021 or 2022 are available. For comparison, output of a version of WaterGAP v2.2d that is calibrated to the same dataset of observed streamflow as WaterGAP v2.2e is provided. Each of the climate forcing-model version combinations is run in two socio-economic settings, histsoc and nosoc. In nosoc, human water use is set to zero and man-made reservoirs are assumed to be non-existant. In the paper connected to this dataset (to be submitted to Geoscientific Model Development), the newest model version, WaterGAP v2.2e is described by providing the modifications to the previous version v2.2d (Müller Schmied et al. 2021) and the corresponding changes in model output. The most important and requested model outputs (total water storage variations, streamflow and water use) are evaluated against observation data. Standard model output is described as well as the specifics of the WaterGAP contribution within the ISIMIP framework. Müller Schmied, H., Cáceres, D., Eisner, S., Flörke, M., Herbert, C., Niemann, C., Peiris, T. A., Popat, E., Portmann, F. T., Reinecke, R., Schumacher, M., Shadkam, S., Telteu, C.-E., Trautmann, T., Döll, P. (2021): The global water resources and use model WaterGAP v2.2d: Model description and evaluation. Geosci. Model Dev., 14, 1037–1079. https://doi.org/10.5194/gmd-14-1037-2021
878 492 - Research DataThe global water resources and use model WaterGAP v2.2e - model output driven by gswp3-era5 and historical setup of direct human impacts2023-10-20Trautmann, TimAckermann, SebastianCáceres, DeniseFlörke, MartinaGerdener, HelenaKynast, EllenPeiris, Thedini AsaliSchiebener, LeonieSchumacher, MaikeAssessing global freshwater resources and human water use is of value for a number of needs but challenging. The global water use and water availability model WaterGAP has been in development since 1996 and has served a range of applications such as assessments of global water resources and water stress, also under the impact of climate change, drought hazard quantification, Life Cycle Assessments, water (over)use and consequently depletion of water resources and a better understanding of terrestrial water storage variations (jointly with satellite observations). Here, the reader can download model output for the time period 1901-2019 that was computed by driving WaterGAP v2.2e by four alternative climate datasets (climate forcings) that were generated in the ISIMIP context (https://www.isimip.org) and are described in https://data.isimip.org/10.48364/ISIMIP.982724. For two climate datasets, model runs up to 2021 or 2023 are available. For comparison, output of a version of WaterGAP v2.2d that is calibrated to the same dataset of observed streamflow as WaterGAP v2.2e is provided. Each of the climate forcing-model version combinations is run in two socio-economic settings, histsoc and nosoc. In nosoc, human water use is set to zero and man-made reservoirs are assumed to be non-existant. In the paper connected to this dataset (in review with Geoscientific Model Development), the newest model version, WaterGAP v2.2e is described by providing the modifications to the previous version v2.2d (Müller Schmied et al. 2021) and the corresponding changes in model output. The most important and requested model outputs (total water storage variations, streamflow and water use) are evaluated against observation data. Standard model output is described as well as the specifics of the WaterGAP contribution within the ISIMIP framework. Müller Schmied, H., Cáceres, D., Eisner, S., Flörke, M., Herbert, C., Niemann, C., Peiris, T. A., Popat, E., Portmann, F. T., Reinecke, R., Schumacher, M., Shadkam, S., Telteu, C.-E., Trautmann, T., Döll, P. (2021): The global water resources and use model WaterGAP v2.2d: Model description and evaluation. Geosci. Model Dev., 14, 1037–1079. https://doi.org/10.5194/gmd-14-1037-2021
499 451 - Research DataA j_eff 12 Kitaev material on the triangular lattice: The case of NaRuO22023-06-07Motivated by recent reports of a quantum disordered ground state in the triangular lattice compound NaRuO$_2$, we derive a $j_{\rm eff}=1/2$ magnetic model for this system by means of first-principles calculations. The pseudospin Hamiltonian is dominated by bond-dependent off-diagonal $\Gamma$ interactions, complemented by a ferromagnetic Heisenberg exchange and a notably \emph{antiferromagnetic} Kitaev term. In addition to bilinear interactions, we find a sizable four-spin ring exchange contribution with a \emph{strongly anisotropic} character, which has been so far overlooked when modeling Kitaev materials. The analysis of the magnetic model, based on the minimization of the classical energy and exact diagonalization of the quantum Hamiltonian, points toward the existence of a rather robust easy-plane ferromagnetic order, which cannot be easily destabilized by physically relevant perturbations.
343 39 - Research DataSection-Type Constraints on the Choice of Linguistic Mechanisms in Research Articles: A Corpus-Based Approach2023This thesis investigates the structure of research articles in the field of Computational Linguistics with the goal of establishing that a set of distinctive linguistic features is associated with each section type. The empirical results of the study are derived from the quantitative and qualitative evaluation of research articles from the ACL Anthology Corpus. More than 20,000 articles were analyzed for the purpose of retrieving the target section types and extracting the predefined set of linguistic features from them. Approximately 1,100 articles were found to contain all of the following five section types: abstract, introduction, related work, discussion, and conclusion. These were chosen for the purpose of comparing the frequency of occurrence of the linguistic features across the section types. Making use of frameworks for Natural Language Processing, the Stanford CoreNLP Module, and the Python library SpaCy, as well as scripts created by the author, the frequency scores of the features were retrieved and analyzed with state-of-the-art statistical techniques. The results show that each section type possesses an individual profile of linguistic features which are associated with it more or less strongly. These section-feature associations are shown to be derivable from the hypothesized purpose of each section type. Overall, the findings reported in this thesis provide insights into the writing strategies that authors employ so that the overall goal of the research paper is achieved. The results of the thesis can find implementation in new state-of-the-art applications that assist academic writing and its evaluation in a way that provides the user with a more sophisticated, empirically based feedback on the relationship between linguistic mechanisms and text type. In addition, the potential of the identification of text-type specific linguistic characteristics (a text-feature mapping) can contribute to the development of more robust language-based models for disinformation detection.
252 10 - Research DataThe global water resources and use model WaterGAP v2.2e - model output driven by gswp3-era5 and historical setup of direct human impacts2023-10-20Trautmann, TimAckermann, SebastianCáceres, DeniseFlörke, MartinaGerdener, HelenaKynast, EllenPeiris, Thedini AsaliSchiebener, LeonieSchumacher, MaikeAssessing global freshwater resources and human water use is of value for a number of needs but challenging. The global water use and water availability model WaterGAP has been in development since 1996 and has served a range of applications such as assessments of global water resources and water stress, also under the impact of climate change, drought hazard quantification, Life Cycle Assessments, water (over)use and consequently depletion of water resources and a better understanding of terrestrial water storage variations (jointly with satellite observations). Here, the reader can download model output for the time period 1901-2019 that was computed by driving WaterGAP v2.2e by four alternative climate datasets (climate forcings) that were generated in the ISIMIP context (https://www.isimip.org) and are described in https://data.isimip.org/10.48364/ISIMIP.982724. For two climate datasets, model runs up to 2021 or 2022 are available. For comparison, output of a version of WaterGAP v2.2d that is calibrated to the same dataset of observed streamflow as WaterGAP v2.2e is provided. Each of the climate forcing-model version combinations is run in two socio-economic settings, histsoc and nosoc. In nosoc, human water use is set to zero and man-made reservoirs are assumed to be non-existant. In the paper connected to this dataset (to be submitted to Geoscientific Model Development), the newest model version, WaterGAP v2.2e is described by providing the modifications to the previous version v2.2d (Müller Schmied et al. 2021) and the corresponding changes in model output. The most important and requested model outputs (total water storage variations, streamflow and water use) are evaluated against observation data. Standard model output is described as well as the specifics of the WaterGAP contribution within the ISIMIP framework. Müller Schmied, H., Cáceres, D., Eisner, S., Flörke, M., Herbert, C., Niemann, C., Peiris, T. A., Popat, E., Portmann, F. T., Reinecke, R., Schumacher, M., Shadkam, S., Telteu, C.-E., Trautmann, T., Döll, P. (2021): The global water resources and use model WaterGAP v2.2d: Model description and evaluation. Geosci. Model Dev., 14, 1037–1079. https://doi.org/10.5194/gmd-14-1037-2021
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