Browsing by Affiliation "Centre for Mental Health"
1 - 4 of 4
- Research DataData for Inflammatory biotype of ADHD is linked to chronic stress: a data-driven analysis of the inflammatory pro-teome2023Protein Data and Grouping variable for the Article "Inflammatory biotype of ADHD is linked to chronic stress: a data-driven analysis of the inflammatory proteome" published in Translational Psychiatry
118 18 - Research DataInhibition of the neurodevelopmental disorder-associated 16p11.2 gene QPRT leads to altered cell type distribution in human stem cell-derived cerebral organoids2026-03-11The 16p11.2 gene QPRT, encoding a key enzyme of the kynurenine pathway, has been linked to neurodevelopmental disorders including autism spectrum disorder (ASD). To investigate its role in early human brain development, we inhibited QPRT in stem cell-derived cerebral organoids. QPRT inhibition resulted in reduced organoid size, driven by premature neural differentiation resulting in depleted progenitor populations. Single-cell transcriptomics revealed an excitation/inhibition imbalance, with reduced excitatory and increased inhibitory neuron populations. We observed metabolic stress signatures, including pseudo-hypoxia, oxidative stress, and mitochondrial dysfunction, likely linked to NAD⁺ depletion and QUIN accumulation following QPRT inhibition. Notably, downregulation of LHX2 and PRDX1 may underlie impaired neural patterning and excitotoxic vulnerability. In addition, we report astrocytic and radial glia dysfunctions, indicating broad effects across multiple cell types. Disease gene enrichment analyses showed significant overlap with ASD-associated genes, especially during early differentiation. These findings suggest the loss or reduction of QPRT to shift neural development and neuronal homeostasis towards an imbalance in excitatory and inhibitory neuronal populations, a mechanism previously associated with neurodevelopmental disorders. Prepublication of the main manuscript is available at bioRxiv https://doi.org/10.1101/2025.09.08.673916
23 10 - Research Data
31 4 - Research DataSupplementary Table 2: Associated MAGMA Genes2025-04-10List of associated genes within MAGMA for each GWAS model.
26 2
